Cholestatic Pruritus (Off-label) 8 mg divided q12hr or 8 mg q8-12hr PO for 7 days up to 5 months
Ondansetron has also been prescribed during pregnancy to help with symptoms of nausea and vomiting in pregnancy (NVP)
3 min read Ondansetron, marketed under the name Zofran, is a medicine that is primarily given to patients to help stop nausea and vomiting caused by cancer treatments
Maximum dose: 16 mg per dose Comments: Multi-day, single-dose administration of 24 mg orally for HEC has not been studied
Nausea and vomiting are common during pregnancy, affecting more than half of all pregnant women
Estimates suggest one out of every four pregnant women receive a prescription for ondansetron
(Funded by the Danish Medical Research Council
3% or Mannitol 10% or Ringers solution; for intermittent infusion, dilute the required dose in 50–100 mL of infusion fluid and give over
Ondansetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation therapy
14 The extensive physiological alterations that occur during pregnancy 15 and the known differences in neonatal drug metabolism 16 may necessitate a dosage adjustment if ondansetron is
Moderately Emetogenic Cancer Chemotherapy
Nausea and Vomiting of Pregnancy: A condition that occurs in early pregnancy, usually starting before 9 weeks of pregnancy
(NVP), its use is common, and approximately 25% of pregnant women are prescribed ondansetron to treat NVP
There are no concerns that ondansetron use in pregnancy affects the chance of miscarriage, stillbirth, preterm delivery or low infant birth weight
Postdischarge management in high-risk patients: Limited data available; of pregnancy and can be detected in fetal tissue (Siu 2006)
The 4-mg dose is taken again 4 and 8 hours after the first dose
Ondansetron comes in three forms that you take by mouth: a tablet, a There was a marked difference in pregnancy history between the exposure groups, with patients exposed to ondansetron being less likely to have a history of live birth (2
Although ondansetron is not specifically approved by the FDA to treat nausea and vomiting during pregnancy (NVP), its use is common, and approximately 25% of pregnant women are prescribed ondansetron to treat NVP
Ondansetron may be taken up to 3 times a day for 1 to 2 days after your chemotherapy or radiation treatment is finished
Zofran During Pregnancy and Breastfeeding
However, it is still controversial regarding its safety during pregnancy, and
Available as ondansetron hydrochloride dihydrate (for oral or IV use) and as ondansetron base (orally disintegrating tablets); dosage expressed in terms of ondansetron