Tablet Extended Release 24 Hour, Oral, as
antianginals
Children—Use and dose must be determined by your
Diltiazem is used to treat high blood pressure (hypertension) and prevent chest pain The dose that’s best for you depends on what condition you’re treating, what diltiazem product you’re taking, and other personal factors
If inadequate give 0
It is available in both liquid and lyophilized states, although the liquid version
The objective of this study was to investigate diltiazem administration in a community ED and determine the effect of varying doses on heart rate (HR) control
The intravenous LD50s in these species were 60 and 38
Comments: Certain container systems of this drug may be inappropriate for the dosage requirements of pediatric patients less than 30 kg
Dose: Comments: Contraindications: Calcium-Channel Blockers; Diltiazem: Bolus 0
25 mg/kg, ranging between 10-20 mg over 2 minutes, with a second dose of 0
If an optimal sedation level is not reached, doses may be readministered every 2 to 3 minutes, up to a maximum dose of 0
Maximum duration of therapy:
For oral dosage form (tablets): Detailed Nitroglycerin dosage information for adults
Computer-based simulations showed that at a daily dose of 480 mg of diltiazem, an 8- to 9-fold mean increase in simvastatin AUC can be expected
Subsequent intravenous bolus doses should be individualized for each
Lower once-daily doses may not maintain full effect at the end of the 24-hour period; larger or more frequent daily
Step 3 = Give the first oral dose ~ 1 hr before titrating down the Diltiazem (Cardizem) is a Class IV antiarrhythmic and one of the most common pharmacological agents used for treatment of AF with RVR
It comes in a few oral forms: immediate-release (IR) tablets and extended-release (ER) tablets and capsules
The usual dosage range studied in clinical trials was 240 to 360
Oral: Initial dose: 2 mg/kg orally once; if the diuretic response to the initial dose is not satisfactory, may increase by 1 or 2 mg/kg and administer no sooner than 6 to 8 hours after the previous dose
35 mg/kg actual body weight over 2 min (average adult dose, 25 mg) direct IV if first dose tolerated but response inadequate; some clinicians suggest additional doses q15min
If desired blood pressure reduction is not achieved at this dose, the infusion rate may be increased by 25 mL/hr (2
High blood pressure is a common condition, and when not treated it can cause damage to the brain, heart, blood vessels, kidneys Following oral administration of extended formulations of 360 mg diltiazem, the drug in plasma was detectable within 3 to 4 hours and the peak plasma concentrations were reached between 11 and 18 hours post-dose